Cannabis and Multiple sclerosis (M.E): reducing the symptoms and stopping disease progression.

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The image illustrates demyelination of axons of neurons that occurs in MS. Source: neurodidacta.es

The image illustrates demyelination of axons of neurons that occurs in MS. Source: neurodidacta.es

A study performed by Cannabinoid Research Group at Universidad complutense de Madrid (UCM) and published in june, reveals that cannabinoids from marihuana could be effective to brake M.E progression. It could be excellent news and additional data mentioning new medicinal effects of Sativex, drug based on phytocannabinoids, which help patients to reduce pain and spasticity in M.E.

Sativex, drug based on phytocannabinoids

Sativex, drug based on phytocannabinoids

It’s an evidence: there is nothing new telling that cannabis, or better, cannabinoids, compounds biosynthetized by the plant , known as phytocannabinoids, are beneficial for people who suffer diseases like M.E, feed disorder or different kinds of cancer. And we don’t say it without evidences; science gives us reasons to agree based on a deep research and numerous reports performed by differents universities in the world, in spite of opposition of the majority of governments to legalize this substance for therapeutic uses.

What till this moment has been discovered was, mainly, that, with cannabis, people were able to reduce pains caused by mentioned diseases (specially in M.E cases), as well as reduce nausea or vomits (in case of chemotherapy indications in persons affected by cancer), improve sleeping in sleep disorders or helping to get appetite when other diseases give a lack of it.

But recently what has been discovered goes beyond. A new study performed by cannabinoids researcher group at Universidad Complutense de Madrid, which is reported by ABC daily newspaper and also published in Neuropharmacology journal, reveals that cannabis, due to its phytocannabinoids could brake M.E progression. If it is confirmed, not only will be good news for scientific community, but for thousands of people around the world that suffer this neurodegenerative desease affecting, mainly, to movility but also to sleep cycle among other negative effects.

Known effects of marihuana for M.E treatment

There are many studies and clinical trials which conclude that cannabis treatment, being swallowed or inhalated, improves symptoms suffered by M.E patients which mainly are: spasticity (permanent muscle contraction), hard pain, lack of sleep, even some of them suffer certain lack of appetite.

It’s true that exists medication to treat these kind of problems, but not always are effective in all people and are a lot of them that have decided to try cannabis as alternative therapy to palliate their symptoms. In a report published in digital daily media adicciones.es sick people to whom cannabis had been tested as alternative therapy ensure to feel better, being smoked the administration via with best results.

Cesamet (Nabilona)

Cesamet (Nabilona)

But this is not the only cannabis characteristic, since also it can act as a natural analgesic. A study published in Neurology journal concludes that cannabis is more effective than placebo in terms of sleep disorder reduction and pain relief, elements which suffer M.E patients. In this case, patients had smoked cannabis.

Other cause which provoke acute pain in M.E patients are myoclonic spasms that make muscles contract in 80% of total M.E patients, symptoms that cannabis can relief, since reduce spasticity rate.

Did you know nerves that help to control mood are affected in 50% of cases in M.E patients? Medicine in general recommends antidepressants but, however, marihuana is a natural antidepressant which helps to reduce depression. It is demonstrated that endocannabinoids develop a main function in mood regulation and in subjective levels of happiness. In these cases, it is recommended to use medicinal products based on CBD extracts with no THC content to avoid psychotropic secondary effects.

Finally is good to mention incontinence problems in M.E or other neurologic disorders. In the study mentioned before among 50% to 60% of patients affirmed that these problems were diminished due to cannabis treatment. A slight improvement were manifested by other people affected of constipation.

Stop M.E progression

As we have mentioned in this report, recently, it has been published a new study performed in Spain, concretely by cannabinoid research group at Universidad Complutense de Madrid.

As we can see in ABC newspaper, which shows all conclusions about the research, the biological base about the positive effects of marihuana was discovered studying the interaction of some compounds that the plant produce, called cannabinoids, with proteins located at cell membranes in neuronal tissue, called cannabinoid receptor type 1 (CB1).

Report continues explaining that “both kinds of receptors (CB1 and CB2) takes part of a communication system specially active in the brain, called endocannabinoid system”.

Due to these conclusions medicine Sativex was created and commercialized, but, deeping in the study, we can say that other synthetic cannabinoids tested, for instance molecule WIN-55,512-2, had great results in a mouse M.E model as a CB1 activator.

Figure 1. a) In animals treated with placebo appear, aggregates of cells that release toxic substances that do not appear in the mice treated with WIN. b) By blocking the CB1 receptor WIN this effect is lost. Source: De Lago et al. Neuropharmacology. 2012.

Figure 1. a) In animals treated with placebo appear, aggregates of cells that release toxic substances that do not appear in the mice treated with WIN. b) By blocking the CB1 receptor WIN this effect is lost. Source: De Lago et al. Neuropharmacology. 2012.

Strains indicated to M.E treatment

Marihuana strains indicated to treat M.E are those which have high CBD content.

Taking this into account, regarding to M.E some of the most recommended strains are the following:

Afgan Kush: 100% índica,This strain can people get relax, helping to reduce muscle pains.

Afgan Kush - World of Seeds

Afgan Kush – World of Seeds

White Rhino: 100% feminised, This sort of strain is ideal to improve mood in general, specially indicated to M.E patients.

White Rhino - Nirvana

White Rhino – Nirvana

Prozakc: mainly índica (80%) , have relaxing and antidepressant effects.

Prozack - Medical Seeds

Prozack – Medical Seeds

By Noelia Jiménez, Team Piensa En Verde

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